Cardiac Sarcoidosis

Cardiac sarcoidosis is a potentially life-threatening inflammatory heart disease that can cause heart failure, arrhythmias, and sudden cardiac death. Despite its clinical severity, the immune mechanisms driving cardiac inflammation remain poorly understood, and current therapies are often non-specific and incompletely effective.

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Our lab uses integrated multi-omics approaches, including single-cell RNA sequencing, spatial transcriptomics, TCR sequencing, CyTOF, and human tissue analysis, to define the immune cell populations and signaling pathways that drive cardiac sarcoidosis. We are particularly interested in pathogenic T-cell states, macrophage–stromal cell interactions, and chemokine signaling networks that promote inflammation within the heart.

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By combining high-dimensional immune profiling with mechanistic mouse and human translational models, we aim to identify novel biomarker and therapeutic strategies that more precisely target cardiac inflammation while minimizing systemic immunosuppression.

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Funding: NHLBI Katz R01, NIH R01, Philanthropy